Global tissue hypoxia

Clinical management of tissue hypoxia usually focuses on global hypoxemia and oxygen delivery. Blood lactate levels rise very rapidly as oxygen delivery to the peripheral tissues decreases below a critical level. An increased blood lactate level is an earlier indicator of tissue hypoxia than pH. Increased blood lactate indicates hypoxia or circulatory failure Lactic acidosis is seen in hypoxia associated with acute cardiac or respiratory failure, shock, and acute blood loss. As we move into the future, the clinical focus needs to change to assessing and managing mission-critical regional hypoxia to avoid unnecessary and potential toxic global strategies.

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Increased blood lactate indicates hypoxia or circulatory failure

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